王后禹 教授 博士生导师
学习工作经历：
2022.07-至今 研究员，苏州大学功能金沙集团186cc成色与软物质研究院
2018.07-2022.06 副研究员，苏州大学功能金沙集团186cc成色与软物质研究院
2016.03-2018.06 助理研究员，苏州大学功能金沙集团186cc成色与软物质研究院
2014.1-2016.03 博士后，苏州大学功能金沙集团186cc成色与软物质研究院，合作导师：何耀 教授
2010.9-2013.12 博士，上海交通大学，导师：曹成喜 教授
2007.9-2010.06 硕士，上海交通大学/上海医药工业研究院，导师： 赵文杰 研究员
2002.9-2006.06 学士，安徽科技学院
所在课题组：何耀 教授课题组
研究方向：生物成像与传感分析
近年来工作集中在不同细菌引起感染的早期诊断上，实现了在体外和体内同时对革兰氏阳性细菌和革兰氏阴性细菌进行高灵敏、高分辨光学成像分析。迄今为止，共发表SCI论文50余篇，其中以第一作者或通讯作者身份发表论文40余篇， 包括Anal. Chem. 13篇、 Nat. Commun. 3篇、 Angew. Chem. Int. Ed. 2篇、 Chem. Sci. 1 篇和Biosens. Bioelectron. 1篇，3项国家专利获得授权。目前负责3门本科生课程的教学，指导本科生在“苏大天宫杯”、“挑战杯竞赛”中获一等奖。迄今为止，培养研究生 30 人，其中包括博士生4 人；硕士生 26 人，江苏省优秀硕士论文1人次。
科研项目：
1. 国家自然科学基金面上项目，22074101，基于微流控硅基SERS-microRNA芯片实现智能化乳腺癌分子分型的研究，2021/01-2024/12，63万元，在研，主持。
2.国家自然科学基金青年项目，21605109，新型硅线阵列多功能芯片构建及其在细菌捕获、拉曼检测与抗菌上的应用，2017/01-2019/12，20万元，已结题，主持。
3.江苏省自然科学基金面上项目，BK20191417，基于深度神经网络的微流控硅基SERS-microRNA芯片，2019/07-2022/06，10万元，在研，主持。
4.中国博士后科学基金面上资助（第55 批），7131701914，基于硅基的微流控IEF-SERS 平台分析检测糖化血红蛋白，2014/04-2016/04，8万元，已结题，主持。）
代表性论文：
[1] Binbin Chu#, Yunmin Yang#, Jiali Tang, Bin Song, Yao He*, Houyu Wang*“Trojan Nanobacteria System for Photothermal Programmable Destruction of Deep Tumor Tissues” Angew. Chem. Int. Ed. 2022, 61, e202208422.
[2] Rong Sun#, Mingzhu Liu#, Jianping Lu, Binbin Chu, Yunmin Yang, Bin Song, Houyu Wang* & Yao He* “Bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles for glioblastoma photothermal immunotherapy” Nat. Commun. 2022, 13, 5127.
[3] Rong Sun#, Mingzhu Liu#, Zhaojian Xu, Bin Song, Yao He*, Houyu Wang* “Silicon-Based Nanoprobes Cross the Blood-Brain Barrier for Photothermal Therapy of Glioblastoma” Nano Res. 2022, 15, 7392-7401.
[4] Jiayi Cheng, Haiting Cao, Yanan Xu, Yunmin Yang, Yao He*, Houyu Wang* “In situ monitoring of dynamic photocatalysis of metal-organic frameworks by three-dimensional shell-isolated nanoparticle-enhanced Raman spectroscopy” Anal. Chem. 2022, 2022, 94, 5699–5706.
[5] Yunmin Yang#, Binbin Chu#, Jiayi Cheng, Jiali Tang, Bin Song, Houyu Wang*, Yao He* “Bacteria Eat Nanoprobes for Aggregation-Enhanced Imaging and Killing Diverse Microorganisms” Nat. Commun. 2022, 13, 1255
[6] Jing Li#, Huayi Shi#, Runzhi Chen, Xiaofeng Wu, Jiayi Cheng, Fenglin Dong, Houyu Wang*; Yao He* “Microfluidic Synthesis of High-Valence Programmable Atom-like Nanoparticles for Reliable Sensing” Chem. Sci. 2021, 12, 896-904.
[7] Binbin Chu#; Ajun Wang#; Liang Cheng; Runzhi Chen; Huayi Shi; Bin Song; Fenglin Dong; Houyu Wang*; Yao He* “Ex Vivo and In Vivo Fluorescence Detection and Imaging of Adenosine Triphosphate” J. Nanobiotechnol. 2021, 19, 187
[8] Huayi Shi, Bin Song, Runzhi Chen, Qiang Zhang, Guyue Hu, Jing Li, Jinhua Wang, Xinyu Meng, Houyu Wang*, Yao He* “Microfluidic-Enabled Ambient-Temperature Synthesis of Ultrasmall Bimetallic Nanoparticles” Nano Res. 2021, 15, 248-254.
[9] Binbin Chu, Houyu Wang*,Yao He* “Fluorescent Silicon-Based Nanomaterials Imaging Technology in Diseases” Chem. Res. Chinese U. 2021, 37, 880-888
[10] Binbin Chu, Sicong Wu, Yunmin Yang, Bin Song, Houyu Wang*, Yao He* “Multifunctional Flavonoid-Silica Nanohydrogel Enables Simultaneous Inhibition of Tumor Recurrence and Bacterial Infection in Post-Surgical Treatment” Small, 2021, 2104578.
[11] Xing Lu, Houyu Wang*, Yao He* “Controllable Synthesis of Silicon-Based Nanohybrids for Reliable Surface-Enhanced Raman Scattering Sensing” Chinese J. Chem. 2021, 40, 734-745.
[12] Sifan Meng, Runzhi Chen, Jingxuan Xie, Jing Li, Jiayi Cheng, Yanan Xu, Haiting Cao, Xiaofeng Wu, Qiang Zhang, Houyu Wang* “Surface-Enhanced Raman Scattering Holography Chip for Rapid, Sensitive and Multiplexed Detection of Human Breast Cancer-Associated MicroRNAs in Clinical Samples” Biosens. Bioelectron. 2021, 190, 113470.
[13] Houyu Wang, Yao He*, Biochemical Sensors：Nanomaterial-Based Biosensing and Application (Chapter5: Silicon-Based Optical Biochemical Sensors), World Scientific Publishing Co. Pte. Ltd., 2021, ISSN:2529-816X.
[14] Miaomiao Tang, Lu Zhang, Bin Song, Xiaoyuan Ji, Chenyu Wang, Houyu Wang, Hua Xu, Yuanyuan Su & Yao He* “Long-Term Fundus Fluorescence Angiography and Real-Time Diagnosis of Retinal Diseases in Non-Human Primate-Animal Models” Nano Res.2021, 14, 3840-3847.
[15] Zhaojian Xu, Manjing Li, Rong Sun, Binbin Chu, Bin Song, Houyu Wang, Yuanyuan Su* and Yao He* “Nanoparticles as A Hedgehog Signaling Inhibitor for the Suppression of Cancer Growth and Metastasis” Nanoscale2021, 13, 11077-11085.
[16] Jiali Tang#, Binbin Chu#, Jinhua Wang, Bin Song, Yuanyuan Su, Houyu Wang*, Yao He* “Multifunctional Nanoagents for Ultrasensitive Imaging and Photoactive Killing of Gram-Negative and Gram-Positive Bacteria” Nat. Commun. 2019, 10, 4057.
[17] Na Chen, Xinyu Meng, Pan Ding, Yuanyuan Su, Houyu Wang*, Yao He* “Biomimetic Preparation of Core-Shell Structured SERS Substrate with Antifouling Ability, Good Stability and Reliable Quantitative Capability” Electrophoresis, 2019, 40, 2172-2179.
[18] Runzhi Chen, Huayi Shi, Xinyu Meng, Yuanyuan Su, Houyu Wang*, Yao He* “Dual-Amplification Strategy-Based SERS Chip for Sensitive and Reproducible Detection of DNA Methyltransferase Activity in Human Serum, Anal. Chem. 2019, 91, 3597-3603.
[19] Binbin Chu #, Sicong Wu #, Xiaoyuan Ji, Runzhi Chen, Bin Song, Jiali Tang, Houyu Wang, Yuanyuan Su, Yao He* “Controllable Silicon Nanostructures Featuring Stable Fluorescence and Intrinsic In Vitro and In Vivo Anti-Cancer Activity” J. Mater. Chem. B, 2019, 7, 6247-6256.
[20] Huayi Shi #, Houyu Wang#, Xinyu Meng, Runzhi Chen, Yishu Zhang, Yuanyuan Su, Yao He * “Setting up a Surface-Enhanced Raman Scattering Database for Artificial-Intelligence-Based Label-Free Discrimination of Tumor Suppressor Genes, Anal. Chem. 2018, 90, 14216-14221.
[21] Xinyu Meng#, Houyu Wang#, Na Chen, Pan Ding, Huayi Shi, Xia Zhai, Yuanyuan Su, and Yao He* “A Graphene–Silver Nanoparticle–Silicon Sandwich SERS Chip for Quantitative Detection of Molecules and Capture, Discrimination, and Inactivation of Bacteria” Anal. Chem. 2018, 90, 5646-5653.
[22] Xiaoyuan Ji#, Bin Song#, Houyu Wang#, Binbin Chu,Yuanyuan Su, Yao He* “Silicon Nanomaterials for Biosensing and Bioimaging Analysis” Front. Chem. 2018, 6, 38.
[23] Yu Shi, Na Chen, Yuanyuan Su, Houyu Wang*, Yao He* “Silicon Nanohybrids-Based SERS Chip Armed with An Internal Standard for Broad-Range, Sensitive and Reproducible Simultaneous Quantification of Lead (II) and Mercury (II) in Real Systems” Nanoscale, 2018, 10, 4010-4018.
[24] Xia Zhai, Bin Song, Binbin Chu, Yuanyuan Su, Houyu Wang*, Yao He* “Highly Fluorescent, Photostable, and Biocompatible Silicon Theranostic Nanoprobes against Staphylococcus Aureus Infections” Nano Res, 2018, 11, 6417-6427.
[25] Daoxia Guo, Xiaoyuan Ji, Houyu Wang, Bin Sun, Binbin Chu, Yu Shi, Yuanyuan Su and Yao He* “Silicon Nanowire-Based Multifunctional Platform for Chemo-Photothermal Synergistic Cancer Therapy. J. Mater. Chem. B, 2018, 6, 3876-3883.
[26] Houyu Wang, Yao He* “Recent Advances in Silicon Nanomaterials-Based Fluorescent Biosensors” Sensors, 2017, 17, 268.
[27] Pan Ding#, Houyu Wang#, Bin Song, Xiaoyuan Ji, Yuanyuan Su, Yao He* “In Situ Live-Cell Nucleus Fluorescence Labeling with Bioinspired Fluorescent Probes” Anal. Chem., 2017, 89, 7861-7868.
[28] Huayi Shi, Na Chen, Yuanyuan Su, Houyu Wang*, Yao He* “Reusable Silicon-Based Surface-Enhanced Raman Scattering Ratiometric Aptasensor with High Sensitivity, Specificity and Reproducibility” Anal. Chem. 2017, 89, 10729-10285.
[29] Binbin Chu, Bin Song, Xiaoyuan Ji, Yuanyuan Su, Houyu Wang*, Yao He* “Fluorescent Silicon Nanorods-Based Ratiometric Sensors for Long-term and Real-time Measurements of Intracellular pH in Live Cells” Anal. Chem. 2017, 89, 12152-12159.
[30] Na Chen, Pan Ding, Yu Shi, Tengyu Jin, Yuanyuan Su, Houyu Wang*, Yao He* “Portable and Reliable Surface-Enhanced Raman Scattering Silicon Chip for Signal-On Detection of Trace Trinitrotoluene Explosive in Real Systems” Anal. Chem. 2017, 89, 5072-5078.
[31] Bin Song, Yiling Zhong, Houyu Wang, Yuanyuan Su and Yao He* “One-Dimensional Silicon Nanoshuttles Simultaneously Featuring Fluorescent and Magnetic Properties” Chem. Commun. 2017, 53, 6957-6960.
[32] Bin Song, Houyu Wang, Yiling Zhong, Binbin Chu, Yuanyuan Su and Yao He* “Fluorescent and Magnetic Anti-Counterfeiting Realized by Biocompatible Multifunctional Silicon Nanoshuttles-Based Security Ink” Nanosacle 2017, 10, 1617-1621.
[33] Yanfeng Zhou, Yun Zhang, Yiling Zhong, Rong Fu, Sicong Wu, Qin Wang, Houyu Wang, Yuanyuan Su, Huimin Zhang* and Yao He* “The In Vivo Targeted Molecular Imaging of Fluorescent Silicon Nanoparticles in Caenorhabditiselegans” Nano Res 2017, 11, 2336-2346.
[34] Airui Jiang, Bin Song, Xiaoyuan Ji, Fei Peng, Houyu Wang, Yuanyuan Su and Yao He* “Doxorubicin-Loaded Silicon Nanoparticles Impregnated into Red Blood Cells Featuring Bright Fluorescence, Strong Photostability, and Lengthened Blood Residency” Nano Res., 2017, 11, 2285-2294.
[35] Houyu Wang, Xiangxu Jiang, Yao He* “Highly Sensitive and Reproducible Silicon-Based Surface-Enhanced Raman Scattering Sensors for Real Applications, Analyst, 2016, 141, 5010-5019.
[36] Yu Shi#, Houyu Wang#, Xiangxu Jiang, Bin Sun, Bin Song, Yuanyuan Su, Yao He* “Ultra-Sensitive, Specific, Recyclable and Reproducible Detection of Lead Ions in Real Systems through a Poly Adenine-Assisted Surface-Enhanced Raman Scattering Silicon Chip” Anal. Chem. 2016, 88, 3723-3729.
[37] Binbin Chu#, Houyu Wang#, Bin Song, Fei Peng, Yuanyuan Su, Yao He* “Fluorescent and Photostable Silicon Nanoparticles Sensors for Real-Time and Long-Term Intracellular pH Measurement in Live Cells” Anal. Chem.2016, 88, 9235-9242.
[38] Houyu Wang#, Yanfeng Zhou#, Xiangxu Jiang#, Bin Sun, Ying Zhu, Hui Wang, Yuanyuan Su, and Yao He* “Simultaneous Capture, Detection, and Inactivation of Bacteria as Enabled by a Surface-Enhanced Raman Scattering Multifunctional Chip” Angew. Chem. Int. Ed. 2015, 54, 5132-5136.
[39] Ying Zhu#, Xiangxu Jiang#, Houyu Wang#, Hui Wan, Bin Sun, Yuanyuan Su, Yao He* “A Poly Adenine-Mediated Assembly Strategy for Designing Surface-Enhanced Resonance Raman Scattering Substrates in Controllable Manners” Anal. Chem. 2015, 87, 6631-6638.
[40] Bin Sun#, Xiangxu Jiang#, Houyu Wang#, Bin Song, Ying Zhu, Hui Wang, Yuanyuan Su, Yao He* “Surface-Enhancement Raman Scattering Sensing Strategy for Discriminating Trace Mercuric Ion (II) from Real Water Samples in Sensitive, Specific, Recyclable, and Reproducible Manners” Anal. Chem. 2015, 87, 1250-1256.
[41] Houyu Wang, Xiangxu Jiang, Shuit-Tong Lee, Yao He* “Silicon nanohybrids-based surface-enhanced Raman scattering sensors”Small, 2014, 10, 4455-4468.
[42] Houyu Wang, Yongting Shi, Jian Yan, Jingyu Dong, Si Li, Hua Xiao, Haiyang Xie, Liu-Yin Fan, Cheng-Xi Cao* “Retardation Signal for Fluorescent Determination of Total Protein Content via Rapid and Sensitive Chip Moving Reaction Boundary Electrophoretic Titration” Anal. Chem. 2014, 86, 2888-2894.
[43] Yun-Yun Tang#, Houyu Wang#, Lu Chen, Si Li, Chen-Gang Guo, Hui-Zhi Fan*, Cheng-Xi Cao*, Liu-Yin Fan “Novel Moving Reaction Boundary-Induced Stacking and Separation of Human Hemoglobins in Slab Polyacrylamide Gel Electrophoresis” Anal. Bioanal. Chem. 2013, 405, 8587-8595.
[44] Houyu Wang, Si Li, Yun-yun Tang, Jing-yu Dong, Liu-yin Fan, Cheng-xi Cao* “Determination of Free Acidic and Alkaline Residues of Protein via Moving Reaction Boundary Titration in Microdevice Electrophoresis” Analyst, 2013, 138, 3544-3551.
[45] Houyu Wang, Cheng-Ye Guo, Chen-Gang Guo, Liu-Yin Fan, Lei Zhang, Cheng-Xi Cao* “A Visual Detection of Protein Content Based on Titration of Moving Reaction Boundary Electrophoresis” Anal. Chim. Acta, 2013, 774, 92-99.
[46] Cheng-ye Guo#, Houyu Wang#, Xiao-Ping Liu, Liu-yin Fan, Lei Zhang, Cheng-xi Cao* “Fast and Selective Determination of Total Protein in Milk Powder via Titration of Moving Reaction Boundary Electrophoresis” Electrophoresis, 2013, 34, 1343-1351.
[47] Jingyu Dong, Si Li, Houyu Wang, Qinghua Meng, Liuyin Fan, Haiyang Xie, Chengxi Cao*, Weibing Zhang “A Simple Boric Acid-Based Fluorescent Focusing for Densing of Glucose and Glycoprotein via Multipath Moving Supramolecular Boundary Electrophoresis Chip” Anal. Chem. 2013, 85, 5884-5891.
联系方式：
办公室：独墅湖校区909-3411
电话：0512-6588-3780
邮箱：houyuwang@suda.edu.cn
责任编辑：杨娟
